Car
Just follow the highways from/to :
A41, Geneva via Chambery
A48, Lyon and Paris
A49, Valence and Marseille
A51, Aix-en-Provence
Grenoble can be difficult to navigate by car, but once you get there the "Park and Ride" parking relais system operated by Semitag-parking (http://www.semitag.com/in...) is a good way of getting around. see trams and buses
Train
Several high speed trains TGV from SNCF (http://www.voyages-sncf.com/) link Paris to Grenoble directly every day, for a three-hours trip of 640 km. Full price is about â¬70 for a one-way ticket. Young people and students will be entitled to a découverte discount which can reduce ticket prices by 25%. Those staying for more than a few months and/or planning to travel by train a lot are advised to purchase a 12-25 card â¬50 which gives 25 to 50% discounts.
Hourly trains link Lyon Part-Dieu station to Grenoble, from 5:30 am to midnight 5am to 10pm from Grenoble to Lyon. This takes around an 1h15 to 1h30 with the TER regional trains (http://www.ter-sncf.com/U...). Full price is 20.20â¬. The train schedule sometimes includes TER buses. The price is the same, the duration is the same, they start at the same station and arrive at the same point.
TER trains also link the city to Geneva in Switzerland 2h, to southern Alps Gap, Sisteron and to Valence 1h where you can change for the TGV to Southern-France.